Week 3 of the college football season delivered another shake-up to the national championship odds, highlighted by Ole Miss spoiling Lane Kiffin’s return to Oxford.
The Rebels defeated Kiffin and LSU 32-24, earning a signature win against their former head coach. As a result, Ole Miss’ odds to win the national championship surged from +2700 to +1500.
Despite its Week 2 loss to Texas, Ohio State remains the favorite after responding with a dominant win over Kent State in Week 3.
Let’s check out the updated odds for who will win the College Football Playoff at DraftKings Sportsbook as of Sept. 20.
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2026 CFP Championship Winner Odds
Ohio State: +520 (bet $10 to win $62 total)
Texas: +620 (bet $10 to win $72 total)
Notre Dame: +650 (bet $10 to win $75 total)
Georgia: +650 (bet $10 to win $75 total)
Miami: +850 (bet $10 to win $95 total)
Indiana: +950 (bet $10 to win $105 total)
Ole Miss: +1500 (bet $10 to win $160 total)
LSU: +1600 (bet $10 to win $170 total)
Oregon: +2200 (bet $10 to win $230 total)
Alabama: +2500 (bet $10 to win $260 total)
USC: +3100 (bet $10 to win $320 total)
Texas Tech: +3200 (bet $10 to win $330 total)
Here is what to know about the oddsboard:
The Favorite: Despite its Week 2 loss to Texas, Ohio State remains the national title favorite at +520. The Buckeyes quickly moved past the heartbreaking loss with a dominant 59-3 win over Kent State in Week 3. With Julian Sayin and Jeremiah Smith leading the offense, Ohio State remains the team to beat.
Kiffin’s Return Spoiled: Ole Miss made the biggest move on the oddsboard after defeating LSU 32-24 and spoiling Lane Kiffin’s return to Oxford. Trinidad Chambliss delivered a signature performance against his former coach, throwing for 363 yards and two touchdowns. As a result, LSU’s odds to win the title dropped from +1100 to +1600.
